ABSTRACT
Background: Studies have reported the controversial association between multiple sclerosis [MS] and celiac disease [CD]. Thus, we aimed to conduct a case control study on patients with MS, CD, and controls to investigate CD in patients with MS by means of comparing CD genetic markers in patients with MS and controls. We also evaluated serological markers in patients with MS
Materials and Methods: This is a case control study conducted on 60 patients with MS, 140 patients with CD, and 151 healthy controls in 2015 in Tehran, Iran. HLA typing was done to identify the carriers of the DQB1*02, DQB1*0301, DQA1*05, or DQA1*0201 alleles for HLA-DQ2, DQB1*0302, or DQA1*03 for HLA-DQ8. All data were analyzed using SPSS software [version 23, IBM Corp]. Serological markers including anti-gliadin antibodies [AGA] [IgA, IgG], anti-tissue trans glutaminase antibodies [Anti tTG] [IgA, IgG], anti-endomysial antibody [EMA] [IgA, IgG], and total IgA were assessed in MS group by enzyme immunoassays
Results: The data of 60 patients with MS [26.7% male, mean age = 34.83 years], 140 patients with CD [33.6% male, mean age = 38.37 years] and 151 controls [48.3% male, mean age = 40.43 years] were analyzed. The results of serological markers were not positive in any of the patients with MS. The prevalence of IgA deficiency [IgA
Conclusion: Our results did not show any correlation between MS and CD, which was similar to other studies